SEN 12333
SEN 12333(N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide)
CAS: 874450-44-9
化学式: C20H25N3O2
| 中文名 | SEN 12333 |
| 英文名 | N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide |
| 英文别名 | SEN 12333 N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide |
| CAS | 874450-44-9 |
| 化学式 | C20H25N3O2 |
| 分子量 | 339.43 |
| 存储条件 | -20℃ |
| 产品用途 | SEN-12333, also known as WAY-31753, is is a selective agonist of the alpha(7) nAChR (EC50 = 1.6 μM, Ki = 260 nM at rat α7 nAChRs). SEN-12333 displayed excellent in vitro and in vivo profiles, excellent brain penetration and oral bioavailability, and demonstrates in vivo efficacy in multiple behavioural cognition models. |
| 参考资料 展开查看 | 1: Xie J, Zhao T, Liu Y. Sonic hedgehog regulates the pathfinding of descending serotonergic axons in hindbrain in collaboration with Wnt5a and secreted frizzled-related protein 1. Int J Dev Neurosci. 2018 May;66:24-32. doi: 10.1016/j.ijdevneu.2017.11.006. Epub 2017 Nov 28. PMID: 29196093. 2: Beinat C, Banister SD, Herrera M, Kassiou M. The Recent Development of α7 Nicotinic Acetylcholine Receptor (nAChR) Ligands as Therapeutic Candidates for the Treatment of Central Nervous System (CNS) Diseases. Curr Pharm Des. 2016;22(14):2134-51. doi: 10.2174/1381612822666160127114125. PMID: 26818858. 3: Beinat C, Reekie T, Banister SD, O'Brien-Brown J, Xie T, Olson TT, Xiao Y, Harvey A, O'Connor S, Coles C, Grishin A, Kolesik P, Tsanaktsidis J, Kassiou M. Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs. Eur J Med Chem. 2015 May 5;95:277-301. doi: 10.1016/j.ejmech.2015.03.025. Epub 2015 Mar 14. PMID: 25827398. 4: Beinat C, Reekie T, Hibbs D, Xie T, Olson TT, Xiao Y, Harvey A, O'Connor S, Coles C, Tsanaktsidis J, Kassiou M. Investigations of amide bond variation and biaryl modification in analogues of α7 nAChR agonist SEN12333. Eur J Med Chem. 2014 Sep 12;84:200-5. doi: 10.1016/j.ejmech.2014.07.029. Epub 2014 Jul 9. PMID: 25019477. |
SEN 12333 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.946 ml | 14.731 ml | 29.461 ml |
| 5 mM | 0.589 ml | 2.946 ml | 5.892 ml |
| 10 mM | 0.295 ml | 1.473 ml | 2.946 ml |
| 5 mM | 0.059 ml | 0.295 ml | 0.589 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: 5-吗啉代-N-(4-(吡啶-3-基)苯基)戊酰胺 去供应商网站查看 询盘CAS: 874450-44-9
产地: 上海
规格: M964634
价格: 25mg-982,100mg-2834,250mg-5215,50mg-1668
库存: 7天内发货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
现货供应
产品名: 5-吗啉代-N-(4-(吡啶-3-基)苯基)戊酰胺 去供应商网站查看 询盘CAS: 874450-44-9
产地: 上海
规格: M964634
价格: 25mg-982,100mg-2834,250mg-5215,50mg-1668
库存: 7天内发货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
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